Achievment
Publications (*, Corresponding author)
- Tokumaru T, Apolinario MEC, Shimizu N, Umeda R, Honda K, Shikano K, Teranishi H, Hikida T, Hanada T, Ohta K, Li Y, Murakami K, Hanada R*.
Hepatic extracellular ATP/adenosine dynamics in zebrafish models of alcoholic and metabolic steatotic liver
Sci Rep. Apr 3;14(1):7813, 2024 - Okanari K, Teranishi H, Umeda R, Shikano K, Inoue M, Hanada T, Ihara K, Hanada R*.
Behavioral and neurotransmitter changes on antiepileptic drugs treatment in the zebrafish pentylenetetrazol-induced seizure model.
Behav Brain Res. 464:114920, 2024 - Mie Kamate, Hitoshi Teranishi, Ryohei Umeda, Kenshiro Shikano, Shiho Kitaoka, Toshikatsu Hanada, Takatoshi Hikida, Kenji Kawano, Reiko Hanada*
Dietary texture-driven masticatory activity and its impact on stress tolerance
Journal of Oral Biosciences. Mar;67(1):100628, 2025
- Ikeuchi M, Inoue M, Miyahara H, Sebastian WA, Miyazaki S, Takeno T, Kiyota K,Yano S, Shiraishi H, Shimizu N, Hanada R, Yoshimura A, Ihara K, Hanada T.
A pH imbalance is linked to autophagic dysregulation of inner ear hair cells in Atp6v1ba-deficient zebrafish.
Biochem Biophys Res Commun. 699:149551, 2024 - Carrasco Apolinario ME, Umeda R, Teranishi H, Shan M, Phurpa, Sebastian W.A, Lai S, Shimizu N, Shiraishi H, Shikano K, Hikida T, Hanada T, Ohta K, Hanada R*.
Behavioral and neurological effects of Vrk1 deficiency in zebrafish.
Biochem Biophys Res Commun. 675: 10-18, 2023 - Ikeda N, Kawasaki M, Baba K, Nishimura H, Fujitani T, Suzuki H, Matsuura T, Ohnishi H, Shimizu M, Sanada K, Nishimura K, Yoshimura M, Maruyama T, Conway-Campbell BL, Onaka T, Teranishi H, Hanada R, Ueta Y, Sakai A.
Chemogenetic Activation of Oxytocin Neurons Improves Pain in a Reserpine-induced Fibromyalgia Rat Model.
Neuroscience. 528:37, 2023 - Umeda R, Teranishi H, Hada K, Shimizu N, Shiraishi H, Urushibata H,Lai S, Shide M, Carrasco Apolinario ME, Higa R, Shikano K, Shin T,Mimata H, Hikida T, Hanada T, *Hanada R.
Vrk2 deficiency elicits aggressive behavior in female zebrafish.
Genes Cells. 27(4): 254-265, 2022 - Teranishi H, Hanada R.
Neuromedin U, a Key Molecule in Metabolic Disorders.
Int J Mol Sci. 22(8): 4238, 2021 - Anan M, Higa R, Shikano K, Shide M, Soda A, Carrasco Apolinario ME, Mori K,Shin T, Miyazato M, Mimata H, Hikida T, Hanada T, Nakao K, Kangawa K,*Hanada R.
Cocaine has some effect on neuromedin U expressing neurons related to the brain reward system. Heliyon 6(5): e03947, 2020 - Fujinami H, Shiraishi H, Hada K, Inoue M, Morisaki I, Higa R, Shin T, Kobayashi T, Hanada R, Penninger JM, Mimata H, *Hanada T.
CLP1 acts as the main RNA kinase in mice.
Biochem Biophys Res Commun.525(1): 129-134, 2020 - Inoue M, Hada K, Shiraishi H, Yatsuka H, Fujinami H, Morisaki I, Matsibara E,Ishitani T, Hanada R, Matsumoto M, Penninger JM, Ihara K, *Hanada T.
Tyrosine pre-transfer RNA fragments are linked to p53-dependent neuronal cell death via PKM2.
Biochem Biophys Res Commun. 525(3)：726-732, 2020 - Yatsuka H, Hada K, Shiraishi H, Umeda R, Morisaki I, Urushibata H, Shimizu N,Sebastian W.A, Hikida T, Ishitani T, Hanada R, Shimada T, Kimoto K, Kubota T,*Hanada T.
Exosc2 deficiency leads to developmental disorders by causing a nucleotide pool
imbalance in zebrafish.
Biochem Biophys Res Commun. 533(4): 1470-1476, 2020 - *Hanada R.
The role of the RANKL/RANK/OPG system in the central nervous systems (CNS).
J Bone Miner Metab. 39(1): 64-70, 2021 - Rao S, Mondragón L, Pranjic B, Hanada T, Stoll G, Köcher T, Zhang P, Jais A,Lercher A, Bergthaler A, Schramek D, Haigh K, Sica V, Leduc M, Modjtahedi N,Pai TP, Onji M, Uribesalgo I, Hanada R, Kozieradzki I, Koglgruber R, Cronin SJ,She Z, Quehenberger F, Popper H, Kenner L, Haigh JJ, Kepp O, Rak M, Cai K,*Kroemer G, *Penninger JM.
AIF-regulated oxidative phosphorylation supports lung cancer development.
Cell Res. 29(7): 579-591, 2019 - Higa R, *Hanada T, Teranishi H, Miki D, Seo K, Hada K, Shiraishi H, Mimata H, Hanada R, Kangawa K, Murai T, Nakao K. CD105
maintains the thermogenic program of beige adipocytes by regulating
Smad2 signaling.
Molecular Cellular Endocrinology. 15; 474:184-193,2018 - Teranishi H, Hayashi M, Higa R, Mori K, Miyazawa T, Hino J, Amano Y, Tozawa R, Ida T, Hanada T, Miyazato M, *Hanada R, Kangawa K, Nakao K.
Role of neuromedin U in accelerating of non-alcoholic steatohepatitis in mice. Peptides. 99: 134-141, 2018
Proceedings
- Hanada R
Pathophysiological role of liver extracellular ATP/ADO in MALFD/MASH using zebrafish model
The Journal of Physiological Sciences. 74(Suppl 2):28,67,2024 - Shikano K, Hanada R
The physiological function of Neuromedin U system in fear memory
The Journal of Physiological Sciences. 74(Suppl 2):28,17,2024 - Umeda R, Sohda A, Kume S, Teranishi H , Shikano K , Hikida T , Hanada R
Understanding the Mechanisms of Microglial Dynamics and the ATP/Adenosine System in Controlling Aggressive Behavior Using the Zebrafish Model
The Journal of Physiological Sciences. 74(Suppl 2):28,196,2024 - Carrasco Apolinario ME, Umeda R, Teranishi H, Shan M, Phurpa, Apridita Sebastian W, Lai S, Shimizu N, Shiraishi H, Shikano K, Hikida T, Hanada T, Ohta K, Hanada R
Behavioral and neurological effects of Vrk1 deficiency in zebrafish
The Journal of Physiological Sciences. 74(Suppl 2):28,211,2024 - Kamate M, Teranishi H, Shikano K, Umeda R, Kawano K, Hanada R
Elucidating the usefulness of mastication in depression
The Journal of Physiological Sciences. 74(Suppl 2):28,286,2024 - Shan M, Umeda R, Kume S, Phurpa, Carrasco Apolinario ME, Shikano K, Teranishi H, Hikida T, Li Y, Hanada R
Evaluation of danger-associated molecular patterns (DAMPs) dynamics in a zebrafish model of gut inflammation
The Journal of Physiological Sciences. 74(Suppl 2):28,288,2024 - Sohda A, Umeda R, Shikano K, Teranishi H, Kume S, Hikida T, Hanada R
Pathophysiological roles of DAMPs for depression using a zebrafish model
The Journal of Physiological Sciences. 74(Suppl 2):28,160,2024 - Phurpa, Umeda R, Kume S, Carrasco Apolinario ME, Shan M, Shikano K, Teranishi H, Hikida T, Li Y, Hanada R
Evaluation of Damage Associated Molecular Patterns (DAMPs) in a Zebrafish model of Heart Failure
The Journal of Physiological Sciences. 74(Suppl 2):28,248,2024 - Kato A, Nishida K, Qianyun Gao, Kitazono T, Yanagisawa M
The analysis of change in subcellular localization of a putative sleep regulator, ARHGEF2 via SIK3
The Journal of Physiological Sciences. 74(Suppl 2):28,174,2024
Invited talks
- Hanada R
The 22nd Meeting of the Japan Endocrine Society of the Kyushu Branch,
September 3rd, 2022, Kumamoto - Hanada R
The 43rd Annual Meeting of the Japan Society for the Study of Obesity / The
40th Annual Meeting of the Japanese Society for the Treatment of Obesity, December 2nd, 2022, Okinawa - Hanada R
The Faculty Development Seminar of the Kyushu University Graduate
school of Medical sciences, December 21st , 2022, WEBINAR(LIVE) - Umeda R
The 6th Japan-Thailand Academic Exchange Seminar, December 12th ,
2022, Oita
Conference Presentations
- Kenshiro Shikano, Ikuko Morisaki, Ryoko Higa, Hitoshi Teranishi, Takaki Yahiro, Mitsuhiro Yoshimura, Toshikatsu Hanada, Kazuhiro Nakamura, Yoichi Ueta, Reiko Hanada
Role of hypothalamic NPGL/NPGM system to energy metabolism
FENS Forum 2024,June 28, 2024, Vienna・Austria - Ryohei Umeda, Nobuyuki Shimizu, Hitoshi Teranishi, Kenshiro Shikano, Hirotaro Urushibata, Hiroshi Shiraishi, Takatoshi Hikida, Toshikatsu Hanada, Reiko Hanada.
Vrk2 deficiency elicits aggressive behavior in female zebrafish
FENS Forum 2024,June 29, 2024, Vienna・Austria - Carrasco Apolinario ME, Umeda R, Teranishi H, Shan M, Phurpa, Sebastian W, Lai S, Shimizu N, Shiraishi S, Shikano K, Hikida T, Hanada T, Ohta K, Hanada R.
EFFECTS OF VRK1 DEFICIENCY ON THE NEUROPHYSIOLOGY AND BEHAVIOR OF ZEBRAFISH
FENS Forum 2024,June 29, 2024, Vienna・Austria - Tokumaru T, M.E. Carrasco Apolinario, Umeda R, Shikano K, Teranishi H, Murakami K, Hanada R
Changes in neurotransmitter ATP/adenosine dynamics in the pathogenesis of metabolic liver diseases
FENS Forum 2024,June 29, 2024, Vienna・Austria - Kenshiro Shikano, Hitoshi Teranishi, Reiko Hanada
The physiological function of NPGL/NPGM system in higher brain function
APPW2025,March 17, 2025, Chiba - Umeda R, Sohda A, Kume S, Teranishi H, Shimizu N, Hanada T, Hikida T, Hanada R
Role of adenosine in the control of aggressive behavior in zebrafish
APPW2025,March 19, 2025, Chiba - Carrasco Apolinario Magdeline E. , Tokumaru Tomoko, Shimizu Nobuyuki, Umeda Ryohei, Honda Koichi, Shikano Kenshiro, Teranishi Hitoshi, Hikida Takatoshi, Hanada Toshikatsu, Ohta Keisuke, Li Yulong, Murakami Kazunari & Hanada Reiko
The Role of Hepatic Extracellular ATP and Adenosine Dynamics in a Zebrafish Model of Liver Steatosis
APPW2025,March 19, 2025, Chiba - Kamate M,Teranishi H,Shikano K,Umeda R,Kawano K,Hanada R
Elucidating the physiological significance of mastication in depression
APPW2025,March 18-19, 2025, Chiba - Shan M, Umeda R,Phurpa, Carrasco Apolinario ME, Shikano K, Teranishi H, Hikida T, Hanada T, Li Y, Hanada R
Novel therapeutic strategies to improve metabolic disfunction-associated steatotic liver disease (MASLD) via the hepatocyte extracellular ATP/adenosine (Ado) system
APPW2025,March 19, 2025, Chiba - Sohda A, Shikano K, Teranishi H, Umeda R, Hanada T, Hikida T, Takayama K, Hanada R
On the role of the NMU system in fear memory
APPW2025,March 19, 2025, Chiba - Phurpa, Umeda R, Kume S, Carrasco Apolinario ME, Shan M, Shikano K, Teranishi H, Hikida T, Hanada T, Li Y, Hanada R
Evaluation of Damage Associated Molecular Patterns (DAMPs) in a Zebrafish model of Heart Failure
APPW2025,March 19, 2025, Chiba - Misato Nakatake, Akinobu Sohda, Ryohei Umeda, Magdeline Elizabeth Carrasco Apolinario, Kenshiro Shikano, Nobuyuki Shimizu, Toshikatsu Hanada, Takatoshi Hikida, Reiko Hanada
Behavioral changes induced by VNUT inhibitor in a zebrafish depression model
APPW2025,March 18-19, 2025, Chiba - Kato A, M Elizabeth Carrasco Apolinario, Shan M, Phurpa, Umeda R, Shikano K,Teranishi H , Hanada R
Ketone bodies improve alcoholic liver disease by reducing extracellular hepatocyte ATP/adenosine levels in Zebrafish
APPW2025,March 17, 2025, Chiba
Awards
- APPW2025（Anatomy-Physiology-Pharmacology Week in 2025）,Undergraduate Poster Award
Awardee: Ami Kato
Title of study: Ketone bodies improve alcoholic liver disease by reducing extracellular hepatocyte ATP/adenosine levels in Zebrafish - The 31st Annual Meeting of the Western Japan Society for the study on Obesity, Young Investigator Awards (YIA）
Awardee: Kenshiro Shikano
Title of study: Role of hypothalamic NPGL/NPGM system on the regulation of feeding and energy metabolism
- The 49th Annual Meeting of the Japan Neuroendocrine Society, Young Investigator Awards (YIA）
Awardee: Kenshiro Shikano
Title of study:Physiological mechanisms of energy metabolism in NPGL/NPGM double knockout mice that exhibit leanness
Fundings
- Grant-in-Aid for JSPS fellows (KAKENHI)
Funding agency: The Ministry of Education, Culture, Sports, Science and Technology (MEXT)
PI: Reiko Hanada
FY: 2024~2025 - Grant-in-Aid for Transformative Research Areas (B) (KAKENHI)
Funding agency: The Ministry of Education, Culture, Sports, Science and Technology (MEXT)
PI: Reiko Hanada
FY: 2021~2024 - Grant-in-Aid for Transformative Research Areas (C) (KAKENHI)
Funding agency: The Ministry of Education, Culture, Sports, Science and Technology (MEXT)
PI: Kenshiro Shikano
FY: 2023~2025 - Grant-in-Aid for Transformative Research Areas (C) (KAKENHI)
Funding agency: The Ministry of Education, Culture, Sports, Science and Technology (MEXT)
PI: Hitoshi Teranishi
FY: 2023~2025
Press Releases and Media Coverage
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- @title @@@@. NHK, Date: mmmm, dddd, 202@,
- @title@@@. Released by Oita University, date: mmmm, dddd, 202@